ACTEL6A Antilichaam - N-terminalgebied: HRP (ARP33350_P050-HRP)

Actin-like 6A

Arp4, ACTL6, BAF53A, INO80K, ARPN-BETA

86

O96019

NP_004292

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit

The immunogen is a synthetic peptide directed towards the N terminal region of human ACTL6A

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.

UBC; BMI1; HECW2; FBXO6; HDAC2; CBX5; UCHL5; ARID1B; RUVBL1; TRRAP; ARID1A; SMARCE1; SMARCC2; SMARCC1; SMARCA4; SMARCA2; UBD; GRB2; INO80E; CAND1; CUL3; CDK9; CDK2; H2AFZ; TP53; UL27; SMARCD1; HDGF; SOX2; SMARCAD1; KAT5; PBRM1; Bcl7b; INO80C; ACTR8; INO80

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Wet Ice

429

ACTL6A

ACTL6A

Rabbit

Actin-like protein 6A

NM_004301

VDFPTAIGMVVERDDGSTLMEIDGDKGKQGGPTYYIDTNALRVPRENMEA