ADAM15 Antilichaam - middengebied HRP (ARP46370_P050-HRP)

ADAM metallopeptidase domain 15

MDC15

8751

Q71S69

NP_997079

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit

The immunogen is a synthetic peptide directed towards the middle region of human ADAM15

ADAM15 is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling.The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

BANP; NUP62; RBPMS; UBC; SP4; FHL3; FBXO6; SH3PXD2A; SRC; PTK6; MAPK3; MAPK1; NCK1; GRB2; SNX30; SH3RF3; SNX9; SH3GLB1; PACSIN3; ARHGEF6; ARHGEF7; SORBS2; YES1; NPHP1; LYN; LCK; HCK; FYN; SH3D19; SH3RF1; SORBS3; SNX33; SORBS1; TRIP13; SH3GL2; ABL1; MAD2L1

HRP: Horseradish Peroxidase

Polyclonal Antibody

IHC, WB

Affinity Purified

0.5 mg/ml

Cow: 86%; Dog: 79%; Guinea Pig: 79%; Horse: 85%; Human: 100%; Mouse: 100%; Pig: 85%; Rabbit: 79%; Rat: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

70kDa

Zhong, J.L., (2008) Mol. Cancer Res. 6 (3), 383-394

Wet Ice

862

ADAM15

ADAM15

Rabbit

Disintegrin and metalloproteinase domain-containing protein 15

NM_207196

QPAAPLCLQTANTRGNAFGSCGRNPSGSYVSCTPRDAICGQLQCQTGRTQ