ADAM17 Proteïne, Rat, Recombinant (Hij)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM17 also plays a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes. ADAM17 may play a prominent role in the Notch signaling pathway, during the proteolytic release of the Notch intracellular domain (from the Notch1 receptor) that occurs following ligand binding.
Ice Packs
-20°C
Beschrijving
ADAM17 Proteïne, Rat, Recombinant (Hij) Beschikbaar in 5 µg. Bestel eenvoudig online met snelle levering.
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