ADAMTS13 Antilichaam

ADAMTS13 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme is the von Willebrand Factor (vWF) -cleaving protease, which is responsible for cleaving at the site of Tyr842-Met843 of the vWF molecule. A deficiency of this enzyme is associated with thrombotic thrombocytopenic purpura.

Western blot: 1:1000, IHC (Paraffin) : 1:10-1:50

Q76LX8

Human

A portion of amino acids 829-858 from the human protein was used as the immunogen for this ADAMTS13 antibody.

WB, IHC, ELISA

Antigen affinity

Antigen affinity purified

This ADAMTS13 antibody is available for research use only.

Aliquot the ADAMTS13 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

In 1X PBS, pH 7.4, with 0.09% sodium azide

Titration of the ADAMTS13 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Cytoplasmic

IHC analysis of FFPE human hepatocarcinoma with ADAMTS13 antibody