Adenovir-9 E4 Orf1 Antilichaam

Adenovirus-9 E4 Orf1 Antibody: The many different serotypes of human adenoviruses (Ad) are divided into six subgroups, of which all Ad subgroup A and B and two subgroup D Ads can elicit tumors in infected rodents. Unlike the Ads from subgroup A and B, the ones from subgroup D, Ad9 and Ad10 elicit estrogen-dependent mammary tumors as opposed to undifferentiated sarcomas. In the case of Ad9, its tumorigenicity is dependent on the product of the open reading frame (ORF) 1 of the early region 4 (E4) . The tumorigenic potential of Ad9 E4 Orf1 depends on a carboxyl-terminal PDZ domain-binding motif that mediates interactions with several different membrane-associated cellular proteins such as MUPP1, PATJ, MAGI-1, ZO-2 and Dlg1. It has been suggested that Ad9 E4 Orf1 may have evolved from an ancestral cellular dUTP pyrophosphatase.

6386282

P89079

P89079

Virus

Unconjugated

Primary Antibodies

Cancer

Adenovirus-9 E4 Orf1 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Adenovirus-9 E4 Orf1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Adenovirus-9 E4 Orf1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

Ad-9 E4 Orf1 antibody can detect 10ng Ad-9 E4 Orf1 peptide in ELISA at 1 μ g/mL.

E4

E4-ORF1

Human adenovirus 9

Shenk T. Adenoviridae: the viruses and their replication, p. 2265-2300 in DM Knipe and PM Howley (ed.) Fields virology, 4th ed.Vol. 2. 2001. Lippincott-Raven Publishers, Philadelphia, PA.

Javier R, Rasha Jr. K, Macdonald GJ, et al. Human adenovirus type 9-induced rat mammary tumors. J. Virol.1991; 65:3192-202.

Javier RT. Adenovirus type 9 E4 open reading frame 1 encodes a transforming protein required for the production of mammary tumors in rats. J. Virol.1994; 68:3917-24.

Weiss RS, Lee SS, Prasad BV, et al. Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTP pyrophosphatase enzymes. 1997; J. Virol.1997; 71:1857-70.

Adenovirus-9 E4 Orf1 Antibody: E4-ORF1, ORF1

ELISA

62510674

Liquid