ADORA2B Antilichaam

The adenosine receptor ADORA2B is a member of the G protein-coupled receptor superfamily and is an integral membrane protein that stimulates adenylate cyclase activity in the presence of adenosine (1,2) . Extracellular adenosine triggers a potent anti-inflammatory response that is mediated in part by ADORA2B including the stimulation of IL-10 production (3-5) . Activation of ADORA2B can also enhance the abundance of regulatory T cells (Tregs), a class of cells that work to constrain inflammation (6) .

136

P29275

NP_000667

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology, Signal Transduction

ADORA2B antibody is affinity chromatography purified via peptide column.

Cat. No. 1405 - Mouse Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rabbit: (80%)

ADORA2B antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

ADORA2B antibody can be stored at 4˚ C for up to one year. Antibodies should not be exposed to prolonged high temperatures.

IgG

ADORA2B antibody is human, mouse and rat reactive. At least two isoforms of ADORA2B are known to exist; this antibody will detect both isoforms. ADORA2B antibody is predicted to not cross-react with ADORA2A.

ADORA2B

Cat. No. 1411 - Mouse Colon Tissue Lysate

Adenosine A2b receptor

Homo sapiens

Pierce KD, Furlong TJ, Selbie LA, et al. Molecular cloning and expression of an adenosine A2b receptor from human brain. Biochem. Biophys. Res. Commun. 1992; 187:86-93.

Thimm D, Schiedel AC, Sherbiny FF, et al. Ligand-specific binding and activation of the human adenosine A (2B) receptor. Biochem. 2013; 52:726-40.

Blackburn MR, Vance CO, Morschl E, et al. Adenosine receptors and inflammation. Handb. Exp. Pharmacol. 2009; 215-69.

Grenz A, Homann D, Eltzschig HK. Extracellular adenosine: a safety signal that dampens hypoxia-induced inflammation during ischemia. Antioxid. Redox Signal. 2011; 15:2221-34.

Adenosine receptor A2b, ADORA2

ELISA, WB, IHC-P, IF

4501951

Liquid