AFAP1L Antilichaam

AFAP1L Antibody: The actin filament-associated protein 1 (AFAP1) -like 1 protein is one of three members in the AFAP1 family of adaptor proteins. Like AFAP1, AFAP1L1 is an actin binding protein that has a role in actin cytoskeleton arrangement, but AFAP1L1 is thought to have a unique function distinct from AFAP1. AFAP1L1 colocalizes with cortactin and localizes to invadosomes, highly dynamic, actin-rich adhesion structures harboring metalloproteases, suggesting that AFAP1L1 affects invadosome formation (1, 4) . Recent reports suggest that AFAP1L1 can be used as a prognostic marker for spindle cell sarcomas.

134265

Q8TED9

NP_689619

Human, Mouse

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

AFAP1L Antibody is affinity chromatography purified via peptide column.

Cat. No. 1203 - A549 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (79%)

AFAP1L Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

AFAP1L antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms of AFAP1L1 are known to exist. This antibody is predicted to not cross-react with other AFAP family members.

AFAP1L1

Cat. No. 17-003 - A549 Cell Slide

Actin filament associated protein 1-like 1

Homo sapiens

Snyder BN, Cho Y, Qian Y, et al. AFAP1L1 is a novel adaptor protein of the AFAP family that interacts with cortactin and localizes to invadosomes. Eur. J. Cell Biol. 2011; 90:376-89

Flynn DC, Leu TH, Reynolds AB, et al. Identification and sequence analysis of cDNAs encoding a 110-kilodalton actin filament-associated pp60src substrate. Mol. Cell. Biol. 1993;13:7892-900.

Baisden JM, Gatesman AS, Cherezova L, et al. The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases. Oncogene 2001; 20:6607-16.

Saltel F, Daubon T, Juin A, et al. Invadosomes: intriguing structures with promise. Eur. J. Cell Biol. 2011; 90:100-7.

AFAP1L Antibody: Actin filament-associated protein 1-like 1, AFAP1-like protein 1

ELISA, WB, ICC, IF

55742689

Liquid