Aficanten-d3
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Aficamten-d3 (CK-274-d3) is deuterium labeled Aficamten. Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used for the research of hypertrophic cardiomyopathy (HCM) [1].
CK-274-d3; CK-3773274-d3
12352005
Isotope-Labeled Compounds; Myosin
Cytoskeleton; Others
Neuroscience-Neuromodulation
Cardiovascular Disease
O=C(N[C@H]1C2=CC=C(C=C2CC1)C3=NOC(CC)=N3)C4=CN(N=C4)C([2H])([2H])[2H]
C18H16D3N5O2
340.39
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Chihyuan Chuang, et al. Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy. J Med Chem. 2021 Oct 14;64 (19) :14142-14152.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W759845/
Isotope-Labeled Compounds
No Development Reported
Beschrijving
Aficamten-d3 (CK-274-d3) is deuterium labeled Aficamten. Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1.4 μM. Aficamten can be used f
Specificaties
Recent bekeken producten
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500 g
GelRed® Agarose LE
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1x 5 g
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D1045S
10x 100 μL
HT115
ACC-130
10 Tubes
Rat Reticulon-4 receptor, RTN4R ELISA Kit
MBS9325746-01
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Starfish Genomic DNA
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NPM2
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15-PGDH Inhibitor Screening Kit (Fluorometric)
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100 Assays
Recent gezochte producten
MS Solution sufficient for 400 Mini, 142 Midi, 33 Maxi
MS10
Each
MS pipette, variable vol µme 10~100 µL
MSP-100
1 Unit
MS 12-ch pipette, variable vol µme 20~200 µL
MSP-12X200
1 Unit
MS 12-ch pipette, variable vol µme 2~20 µL
MSP-12X20
1 Unit
MS Rocking anti-moistured shaker with 30 x 30 cm platform and flat non-slip rubber mat
MS-NRK-3001
1 Unit
MS Orbital Shaker with 30 x 30 cm platform and flat non-slip rubber mat
MS-NOR-30
1 Unit
MS Reciprocal anti-moistured shaker with 30 x 30 cm platform and flat non-slip rubber mat
MS-NRC-3001
1 Unit
MS pipette, variable vol µme 1000~10000 µL
MSP-10000
1 Unit