AF/LE Gezuiverd Anti-Rat Cd8a Antilichaam[OX-8]

CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α (CD8a) /β (CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

Cd8a

P07725

Rat

Recombinant Rat CD8a protein

MAL, T-cell surface glycoprotein CD8 alpha chain, T-lymphocyte differentiation antigen T8/Leu-2, Cd8a, T-lymphocyte differentiation antigen T8/Leu

OX-8

None (AF/LE)

FCM

>98%, Protein A/G purified

≥ 1 mg/mL

66

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Ice bag

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Mouse IgG1, κ