AF/LE Gezuiverde antimens CD152 Antilichaam[9D9]

CTLA-4 and CD28, together with their ligands B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T- and B-cell responses. CTLA-4 and CD28 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CTLA-4 and CD28 are composed of a single Ig V‑like extracellular domain, a transmembrane domain and an intracellular domain. CTLA-4 and CD28 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on Human chromosome 2. CTLA-4 was originally identified as a gene that was specifically expressed by cytotoxic T lymphocytes. However, CTLA-4 transcripts have since been found in both Th1 and Th2, and CD4+ and CD8+ T cell clones. Whereas, CD28 expression is constitutive on the surfaces of 95% of CD4+ T cells and 50% of CD8+ T cells and is down regulated upon T cell activation, CTLA-4 expression is upregulated rapidly following T cell activation and peaks approximately 24 hours following activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with 20-100-fold higher affinity than CD28. The physiological role of CTLA-4 in T cell costimulation is currently being studied.

CD152

12477

P09793

Human

Recombinant Human CD152 protein

GRD; Cytotoxic T-lymphocyte protein; Cytotoxic T-lymphocyte-associated antigen; IDDM; CELIAC; CELIAC3; CTLA-4; Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; GRD4; GSE; IDDM12; Cd152; Ctla4; Ly-56; Ctla4; Ly-56

9D9

None (AF/LE)

FCM

>98%, Protein A/G purified

≥ 1 mg/mL

66

Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.

Ice bag

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

https://789.bio/eb/H1LokXqL

Mouse IgG2b, κ