Afloqualon-d7

Afloqualone-d7 (HQ-495-d7) is deuterium labeled Afloqualone. Afloqualone (HQ-495) is an orally active central muscle relaxant and antivertiginous agent that can increase the sensitivity of GABA receptors in neurons of the lateral vestibular nucleus. Afloqualone (HQ-495) can be used in the research of low back pain and neck-arm-shoulder syndrome[1][2][3].

HQ-495-d7

12352005

GABA Receptor; Isotope-Labeled Compounds

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Neuroscience-Neuromodulation

Neurological Disease

O=C1N(C2=C([2H])C([2H])=C([2H])C([2H])=C2C([2H])([2H])[2H])C(CF)=NC3=C1C=C(N)C=C3

C16H7D7FN3O

290.34

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Y Kudo, et al. Effects of afloqualone on vestibular nystagmus and the lateral vestibular nucleus. Jpn J Pharmacol. 1989 Aug;50 (4) :515-9.|[3]A INOUE, et al. Clinical Effect of Afloqualone (HQ-495) on Low Back Pain and Neck-Arm-Shoulder Syndrome By a Double Blind Trial in Comparison with Tolperisone. Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 1981, 12 (1) : 137-154.|[4]T Ochiai, et al. Pharmacological studies on 6-amino-2-fluoromethyl-3- (O-tolyl) -4 (3H) -quinazolinone (afloqualone), a new centrally acting muscle relaxant. (II) Effects on the spinal reflex potential and the rigidity. Jpn J Pharmacol. 1982 Jun;32 (3) :427-38.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B1833S/

Isotope-Labeled Compounds

No Development Reported