AFX (fosfo Ser197) Antilichaam

Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle.

4303

P98177

NP_001164402.1

Human, Mouse, Rat

AFX (Phospho-Ser197) antibody was raised against a peptide sequence around phosphorylation site of serine 197 (A-A-S (p) -M-D) derived from Human AFX.

Unconjugated

Primary Antibodies

Phospho-Specific, Apoptosis, Cancer

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

65 kDa

This antibody detects endogenous level of AFX only when phosphorylated at serine 197.

Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200

FOXO4

Forkhead box O4

Homo sapiens

Di Maira G, et al. (2005) Cell Death Differ; 12 (6) : 668-77. Essers MA, et al. EMBO J 2004 Nov. 11. Brownawell AM, (2001) Mol Cell Biol; 21 (10) : 3534-46. Kops GJ, et al. (1999) Nature; 398 (6728) : 630-4.

AFX, AFX1, MLLT7, EIF2A, AFX, FOXO4, Afxh

WB, IHC, IF

283436083

Liquid