AG-490
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
A potent inhibitor of the JAK-2 tyrosine kinase. In acute lymphoblastic leukemia (ALL) cells, which abundantly express JAK-2, AG-490 dose-dependently blocked cell growth, induced apoptosis and inhibited DNA synthesis. Blocks the growth of all pre-B ALL cells with no effect on normal B or T cells. Does not significantly inhibit other kinases such as Lck, Lyn, Btk, Syk and Src. Reduces liver injury in LPS-induced shock3. A useful tool for exploring the role of JAK2/STAT3 pathway in physiologic processes4.
Unconjugated
Tan solid
-20°C
Beschrijving
AG-490 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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