AG01

AG01 is a monoclonal antibody against progranulin (GP88) . AG01 inhibits triple-negative breast cancer (TNBC) cell proliferation and migration, reduces the expression of phosphorylated protein kinases p-Src, p-AKT, and p-ERK, and reduces the expression of oncogenic proteins such as Axl, c-MET, HIF-1α, and VEGF. AG01 inhibits tumor growth and Ki67 expression in a TNBC xenograft mouse model. AG01 can be used in the research of TNBC and other cancers[1].

12352100

Akt; c-Met/HGFR; ERK; HIF/HIF Prolyl-Hydroxylase; MMP; Src; TAM Receptor; VEGFR

MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Cancer-Kinase/protease

Cancer

[1]Guha R, et al. Anti-progranulin/GP88 antibody AG01 inhibits triple negative breast cancer cell proliferation and migration. Breast Cancer Res Treat. 2021 Apr;186 (3) :637-653.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P991664/

Inhibitory Antibodies

No Development Reported

Axl; ERK1; ERK2; HIF-1α; MMP-2