AGA Antilichaam

This gene encodes a member of the N-terminal nucleophile (Ntn) hydrolase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta chains that comprise the mature enzyme. This enzyme is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. Mutations in this gene are associated with the lysosomal storage disease aspartylglycosaminuria that results in progressive neurodegeneration. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is subject to proteolytic processing.

175

P20933

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 24-346 of human AGA (NP_000018.2) .

Unconjugated

Primary Antibodies

Other

Affinity purification

SW620

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 18kDa

IgG

AGA

THP-1

HepG2

Mouse liver

Mouse pancreas

Aspartylglucosaminidase

Homo sapiens

AGU, ASRG, GA, N (4) - (beta-N-acetylglucosaminyl) -L-asparaginase, N4- (N-acetyl-beta-glucosaminyl) -L-asparagine amidase, aspartylglucosylamine deaspartylase, glycosylasparaginase

WB, IF

Liquid