AGEN-2373
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
AGEN-2373 is a conditionally active agonist antibody targeting the co-stimulatory receptor CD137. GEN-2373 binds to CD137 without disruption of ligand binding. AGEN-2373 stimulates CD137 under receptor clustering conditions. AGEN-2373 can enhance T cell activity when combined with other checkpoint modulators (e.g. PD-1 antagonist and OX40 agonist) . AGEN-2373 can be studied in research for human malignancies[1].
12352203
TNF Receptor
Apoptosis
COVID-19-immunoregulation
Cancer; Inflammation/Immunology
[1]Claire Galand, et al., AGEN2373 is a conditionally-active agonist antibody targeting the co-stimulatory receptor CD137 for the treatment of human malignancies. Journal of Clinical Oncology, 2019.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991529/
Inhibitory Antibodies
No Development Reported
Beschrijving
AGEN-2373 is a conditionally active agonist antibody targeting the co-stimulatory receptor CD137. GEN-2373 binds to CD137 without disruption of ligand binding.
Specificaties
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