AGI-5198
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
AGI-5198 is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) .1 It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2 This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) form alpha-ketoglutarate (2-OG) .
Unconjugated
White solid
-20°C
Beschrijving
AGI-5198 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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