AGT Antibody - N-terminal regio : HRP (ARP43614 P050-HRP)

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

ANHU, hFLT1, SERPINA8

183

P01019

NP_000020

Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep

The immunogen is a synthetic peptide directed towards the N terminal region of human AGT

AGT, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

ATP6AP2; REN; ACE; ACE2; MME; ECE1; GSDMB; ITSN2; TP53; GRB2; PRG2; ENPEP; PRCP; PREP; MEP1A; AGTR2; KNG1; MAS1; EWSR1; CMA1; CTSG; AGTR1; AGT; DNPEP

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

AGT is supported by BioGPS gene expression data to be expressed in HepG2

0.5 mg/ml

Dog: 92%; Horse: 85%; Human: 100%; Mouse: 86%; Rabbit: 92%; Rat: 93%; Sheep: 77%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

53kDa

Ravn, L.S., (2008) Pharmacogenet. Genomics 18 (6), 525-533

Wet Ice

485

AGT

AGT

Rabbit

Angiotensinogen

NM_000029

IHPFHLVIHNESTCEQLAKANAGKPKDPTFIPAPIQAKTSPVDEKALQDQ