AH-D-peptide (TFA)

AH-D peptide TFA is an antiviral peptide that selectively disrupts membrane structures within the size range of exosomes, inducing T-EXO depletion and enhancing cancer immunotherapy[1].

12352209

Virus Protease

Anti-infection

Cancer; Infection

98.78

OC(C(F)(F)F)=O.O=C([C@H](N)CO)NCC(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N[C@@H](C(N)=O)CC(C)C)=O)CCCCN)=O)CO)=O)CCC(N)=O)=O)CC(C)C)=O)CC1=CNC2=CC=CC=C12)=O)[C@H](C)O)=O)CCCCN)=O)CC3=CC=CC=C3)=O)CC(O)=O)=O)[C@H](C)O)=O)CC(C)C)=O)C(C)C)=O)[C@H](C)O)=O)CS)=O)[C@@H](CC)C)=O)CC4=CNC5=CC=CC=C45)=O)CC(O)=O)=O)CC6=CNC7=CC=CC=C67)=O)C(C)C)=O)CC(O)=O)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC8=CNC9=CC=CC=C89)=O)CO)=O.[x]

C154H228N38O40S.xC2HF3O2

3283.75 (free base)

[1]Sol Shin, et al. Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy. Nat Mater. 2023 May;22 (5) :656-665.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10862A/AH-D-peptide-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported