AIMP2 Antilichaam

AIMP2 was initially identified as a part of an aminoacyl-tRNA synthesase complex (1) . It was later discovered to be a cofactor and substrate of Parkin, a Ring-type E3 ubiquitin ligase that is important for the survival of dopamine neurons in Parkinson's disease; accumulation of AIMP2 in these cells lead to catecholaminergic cell death (2) . AIMP2 can also bind to TRAF2, a key player in the TNF-alpha signaling pathway, causing the ubiquitination of TRAF2 by cIAP1, leading to TNF-alpha-dependent apoptosis (3) . Finally, AIMP2 has been suggested to function as a tumor suppressor (4) .

7965

Q13155

NP_006294

Human

Unconjugated

Primary Antibodies

Apoptosis

AIMP2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

AIMP2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

AIMP2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

AIMP2 antibody is human specific. AIMP2 antibody is predicted to not cross-react with AIMP1.

AIMP2

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 2

Homo sapiens

Quevillon S, Robinson JC, Berthonneau E, et al. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. J. Mol. Biol. 1999; 285:183-95.

Ko HS, von Coelln R, Sriram SR, et al. Accumulation of the authentic parkin substrate aminoacyl-tRNA synthetase cofactor, p38/JTV-1, leads to catecholaminergic cell death. J. Neruosci. 2005; 25:7968-78.

Choi JW, Kim DG, Park MC, et al. AIMP2 promotes TNFalpha-dependent apoptosis via ubiquitin-mediated degradation of TRAF2. J. Cell Sci. 2009; 122:2710-5.

Choi JW, UM JY, Kundu JK, et al. Multidirectional tumor-suppressive activity of AIMP2/p38 and the enhanced susceptibility of AIMP2 heterozygous mice to carcinogenesis. Carcinogenesis 2009; 30:1638-44.

AIMP2 Antibody: P38, JTV1, JTV-1, PRO0992, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2, Multisynthase complex auxiliary component p38

ELISA, WB, IHC-P, IF

11125770

Liquid