AIRE Antilichaam

This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED) .

326

O43918

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human AIRE (NP_000374.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Immunology

Affinity purification

Raji

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 50kDa

IgG

AIRE

BxPC-3

HepG2

Mouse thymus

Rat thymus

Autoimmune regulator

Homo sapiens

AIRE, APS1, APSI, PGA1, AIRE1, APECED

WB, IHC

Liquid