AIRE Antilichaam - N-terminaal gebied : HRP (ARP32649_T100-HRP)

Autoimmune regulator

APS1, APSI, PGA1, AIRE1, APECED

326

O43918

NP_000374

Human, Rat, Cow, Dog, Horse, Pig

The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE

AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD) . Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) .

TUBB; RAVER1; TUBA1C; TMPRSS13; CCDC87; FAT1; GIGYF2; SRRM2; TUBB4B; EIF4EBP3; UBB; HSP90AB1; HSPA8; HSPA5; HSPA1L; HSPA1A; ATP4A; HIST3H3; HDAC2; HDAC1; DAXX; AIRE; UBAC1; HIST1H3A; HIST2H2BE; HSPA4; SRSF1; SMC1A; XPO1; TOP2A; SSRP1; SNRPD3; SNRPB; SRSF3

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

0.5 mg/ml

Cow: 79%; Dog: 92%; Horse: 86%; Human: 100%; Pig: 93%; Rat: 79%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

58kDa

Tao, Y., et al., (2006) Mol. Immunol. 43 (4), 335-345

Wet Ice

545

AIRE

AIRE

Rabbit

Autoimmune regulator

NM_000383

DFWRVLFKDYNLERYGRLQPILDSFPKDVDLSQPRKGRKPPAVPKALVPP