AIRE (fosfo Ser156) Antilichaam

The function of the protein encoded by this gene is not well defined, however it contains zinc finger motifs suggestive of a transcription factor. The protein (isoform 1) is localized to both the nucleus and cytoplasm. Three splice variant mRNAs products have been described [1]. The longer AIRE-1 mRNA appears to be more abundant and includes exons 1 through 14. Splice variant AIRE-2 includes a portion of the non-coding region of exon 1, an alternatively spliced longer exon 8, plus exons 9 through 14. Variant AIRE-3 includes the same exon 1-8-9 sequences as found in AIRE-2 but utilizes additional alternative splicing in exon 10 that shifts the reading frame such that a stop codon in exon 12 is utilized.

326

O43918

NP_000374.1

Human

AIRE (phospho Ser156) antibody was raised against a peptide sequence around phosphorylation site of Serine156 P-G-S (p) -Q-L) derived from Human AIRE.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

50 kDa

IgG

The antibody detects endogenous levels of AIRE only when phosphorylated at serine 156.

Western Blot: 1:500~1:1000

AIRE

Autoimmune regulator

Homo sapiens

Nagamine K., Nat. Genet. 17:393-398 (1997) .

Aaltonen J., Nat. Genet. 17:399-403 (1997) .

Hattori M., Nature 405:311-319 (2000) .

AIRE1, APECED, APS1, APSI, PGA1

WB

4557291

Liquid