AJAP1 Antilichaam

The Adherens Junction Associated Protein 1 (AJAP1) plays a key role in cell adhesion and cell migration (1) . It is a transmembrane protein found on the basolateral surface of epithelium and expressed by multiple types of epithelium (1,2) . AJAP1 interacts with E-Cadherin and appears to promote the internalization of E-Cadherin upon growth factor stimulation (3) . This facilitates the dissolution of adherens junctions with an increase in cell motility (3,4) .

55966

Q9UKB5

NP_061324

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis, Cancer

AJAP1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1464 - Rat Liver Tissue Lysate

1 mg/mL

AJAP1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

AJAP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

AJAP1 antibody is human, mouse and rat reactive.

AJAP1

Cat. No. 17-004 - K-562 Cell Slide

Adherens junctions associated protein 1

Homo sapiens

Zeng L, Fee BE, Rivas MV, et al. Adherens junctional associated protein-1: a novel 1p36 tumor suppressor candidate in gliomas (Review) . Int. J. Oncol. 2014; 45:13-7.

Han L, Zhang KL, Zhang JX, et al. AJAP1 is dysregulated at an early stage of gliomagenesis and suppresses invasion through cytoskeleton reorganization. CNS Neurosci. Ther. 2014; 20:429-37.

Gross JC, Schreiner A, Engels K, et al. E-cadherin surface levels in epithelial growth factor-stimulated cells depend on adherens junction protein shrew-1. Mol. Biol. Cell 2009; 20:3598-607.

Lin N, Di C, Bortoff K, et al. Deletion or epigenetic silencing of AJAP1 on 1p36 in glioblastoma. Mol. Cancer Res. 2012; 10:208-17.

Adherens junctions associated protein 1, Membrane protein shrew-1, MOT8, SHREW1

ELISA, WB, ICC

9055278

Liquid