AKAP4 Antilichaam

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell (1) . AKAP4, also known as hAKAP82, is a major sperm fibrous sheath protein that localizes to the entire length of the flagellum of human sperm (2) . It has been suggested that AKAP4 plays multiple roles in sperm motility and regulation of signal transduction pathways (2) . AKAP4 has also been postulated to be a potential biomarker for breast cancer (3) .

8852

Q5JQC9

NP_003877

Human

Unconjugated

Primary Antibodies

Signal Transduction

AKAP4 antibody is affinity chromatography purified via peptide column.

Cat. No. 1313 - Human Testis Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Rat: (94%), Mouse: (88%)

AKAP4 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

AKAP4 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

AKAP4 antibody is human specific. At least three isoforms are known to exist; this antibody will detect the two longest isoforms.

AKAP4

Cat. No. 11-701 - Human Testis Tissue Slide

A kinase (PRKA) anchor protein 4

Homo sapiens

Carnegie GK, Means CK, and Scott JD. A-kinase anchoring proteins: from protein complexes to physiology and disease. IUBMB 2009; 61:394-406.

Turner RM, Johnson LR, Haig-Ladewig L, et al. An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail. J. Biol. Chem. 1998; 273:32135-41.

Saini S, Jagadish N, Gupta A, et al. A novel cancer testis antigen, A-kinase anchor protein 4 (AKAP4) is a potential biomarker for breast cancer. PLoS One 2013; 8:e57095.

A-kinase anchor protein 4, AKAP-4, AKAP82, hAKAP82, CT99, FSC1, HI, PRKA4

ELISA, WB, IHC-P, IF

21493037

Liquid