AKAP5 Antilichaam - middengebied HRP (ARP36322_P050-HRP)

A kinase (PRKA) anchor protein 5

H21, AKAP75, AKAP79

9495

P24588

NP_004848

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Yeast

The immunogen is a synthetic peptide directed towards the middle region of human AKAP5

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP5 is a member of the AKAP family. It binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT.The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

PRKACB; PRKACA; UBC; PRKCA; CALM1; GABRB1; GABRB3; IQGAP1; DLG4; DLG1; KCNJ2; PRKAR2B; PRKAR2A; RET; PPP3CA; ADRB2; Gria1; Grin2b

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 86%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 79%; Pig: 86%; Rat: 79%; Yeast: 82%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

47kDa

Lu, R. (2008) J. Biol. Chem. 283 (17), 11445-11452

Wet Ice

427

AKAP5

AKAP5

Rabbit

A-kinase anchor protein 5

NM_004857

KQFLISAENEQVGVFANDNGFEDRTSEQYETLLIETASSLVKNAIQLSIE