AKAP8 Antilichaam / A-kinase ankereiwit 8 / AKAP 95

AKAP8 is an anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase. Acts as an anchor for a PKA-signaling complex onto mitotic chromosomes, which is required for maintenance of chromosomes in a condensed form throughout mitosis. Recruits condensin complex subunit NCAPD2 to chromosomes required for chromatin condensation; the function appears to be independent from PKA-anchoring. [UniProt]

Western blot: 1:500-1:2000

O43823

Human

A synthetic peptide specific to human A-kinase anchor protein 8 was used as the immunogen for the AKAP8 antibody.

29A07

WB

Affinity chromatography

Purified

This AKAP8 antibody is available for research use only.

Store the AKAP8 antibody at -20°C.

Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA

Optimal dilution of the AKAP8 antibody should be determined by the researcher.

Western blot testing of human HepG2 cell lysate with AKAP8 antibody. Predicted molecular weight ~76 kDa but routinely observed at ~95 kDa.