Akirin2 Antilichaam

Akirin2 Antibody: The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-κ B-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-κ B pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-α and IL-1β signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

55122

Q53H80

EAW48578

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

Akirin2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%)

Akirin2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Akirin2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

AKIRIN2

Akirin 2

Homo sapiens

Goto A, Matsushita K, Gesellchen V, et al. Akirins are highly conserved nuclear proteins required for NF-kappaB-dependent gene expression in drosophila and mice. Nat. Immunol.2008; 9:97-104.

Beutler B and Moresco EM. Akirins versus infection. Nat. Immunol.2008; 9:7-9.

Sutterwala FS and Flavell RA. Immunology: cascade into clarity. Nature2008; 451:254-5.

Tanji T and Ip YT. Regulators of the Toll and Imd pathways in the Drosophila innate immune response. Trends Immunol.2005; 26:193-8.

Akirin2 Antibody: FBI1, C6orf166, dJ486L4.2, Akirin-2

ELISA, WB

119568963

Liquid