Akt (fosfo Ser129) Antilichaam

General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) . Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase.

207

P31749

NP_001014431.1

Human, Mouse, Rat

Akt (phospho Ser129) antibody was raised against a peptide sequence around phosphorylation site of serine129 (D-N-S (p) -G-A) derived from Human Akt .

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

65 kDa

IgG

The antibody detects endogenous level of Akt only when phosphorylated at serine 129.

Western Blot: 1:500~1:1000

AKT1

V-akt murine thymoma viral oncogene homolog 1

Homo sapiens

Nguyen le XT, Mitchell BS (2013) Proc Natl Acad Sci U S A 110, 20681-6

Ponce DP, et al. (2011) Mol Cell Biochem 356, 127-32

Siddiqui-Jain A, et al. (2010) Cancer Res 70, 10288-98

AKT, AKT1 kinase, kinase Akt1, RAC, RAC-PK-alpha

WB

62241013

Liquid