AKT1 Antilichaam

Serine/threonine protein kinase; Murine thymoma viral (v-akt) oncogene homolog-1. AKT1 is a serine-threonine protein kinase. It is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery.

207

P31749

NP_005154.1

Human, Mouse, Rat, Bovine, Frog

2-200

Unconjugated

Primary Antibodies

Apoptosis, Neuroscience, Signal Transduction, Cancer

Antigen affinity-purified

1 mg/mL

Phosphate-Buffered Saline. No preservatives added.

None

Blue Ice

AKT1 antibody can be stored at 4˚ C for short term (weeks) . Long term storage should be at -20˚ C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

55.7 kDa (calculated)

AKT antibody can be used for the detection of AKT by Western blot, may also work for IHC and ICC.

AKT1

V-akt murine thymoma viral oncogene homolog 1

Homo sapiens

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J. and Greenberg, M. E. TITLE Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor JOURNAL Cell 96 (6), 857-868 (1999) .

PKB, RACProtein kinase B, PKB, AKT, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA

WB

4885061

Liquid