AKT2 Antilichaam - middengebied: HRP (ARP30321_P050-HRP)

V-akt murine thymoma viral oncogene homolog 2

PKBB, PRKBB, HIHGHH, PKBBETA, RAC-BETA

208

P31751

NP_001617

Human, Mouse, Rat, Cow, Dog, Horse, Pig, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human AKT2

AKT2 belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene encoding AKT2 was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. AKT2 is a general protein kinase capable of phophorylating several known proteins.This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

CLIP3; CHUK; PLEKHO1; PRKCZ; UBC; EGFR; POLR1B; SNX27; PNPLA3; STEAP4; ABCG8; POFUT1; TMED2; NAMPT; SORBS2; SPRR2A; CCL14; PRKDC; MAP3K5; HSP90AA1; APOB; APOA1; APPL1; APP; FSHR; VIM; SKI; GRK5; SH3RF1; ESR1; TTC3; SETDB1; XIAP; AKT1S1; TRIB3; PDPK1; GSK3

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB, IHC

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

56kDa

Tan, Y., (2008) Cancer Res. 68 (5), 1296-1302

Wet Ice

481

AKT2

AKT2

Rabbit

RAC-beta serine/threonine-protein kinase

NM_001626

TSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR