Ala-parafluorPhe-Arg-Cha-Cit-Tyr-NH2 (TFA)

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 TFA, a bioactive peptide, is a selective Protease activating receptor 1 (PAR-1) agonist over PAR-2. PAR-1 belongs to a subfamily of G-protein coupled receptors and is known to mediate the cellular effects of thrombin. In addition to its varied cellular effects of thrombin, PAR-1 has also been shown to coordinate with PAR-4 and regulate thrombin-induced hepatocellular carcinoma harboring thrombin formation within the tumor environment classified as 'coagulation type'[1].

12352209

Protease Activated Receptor (PAR)

GPCR/G Protein

Cancer

99.78

O=C(O)C(F)(F)F.O=C(N[C@@H](CC1=CC=C(F)C=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC2CCCCC2)C(N[C@@H](CCCNC(N)=O)C(N[C@@H](CC3=CC=C(C=C3)O)C(N)=O)=O)=O)=O)=O)[C@H](C)N.[x]

C42H63FN12O8.xC2HF3O2

883.02 (free base)

[1]Kawabata A, et al. Evaluation of proteinase-activated receptor-1 (PAR1) agonists and antagonists using a cultured cell receptor desensitization assay: activation of PAR2 by PAR1-targeted ligands. J Pharmacol Exp Ther. 1999 Jan;288 (1) :358-70.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P5372A/Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported

PAR1