[Ala92]-p16 (84-103)

[Ala92]-p16 (84-103) is a peptide derived from the p16CDKN2/INK4a (p16) tumor suppressor protein. [Ala92]-p16 (84-103) binds to both cdk4 and cdk6 and inhibits cdk4-cyclin D1 kinase activity in vitro (IC50: 1.5 μM) . [Ala92]-p16 (84-103) blocks cell cycle progression through the G1 phase[1].

189064-08-2

12352209

CDK

Cell Cycle/DNA Damage

Cancer

98.16

H2O : 20 mg/mL (ultrasonic)

[Asp-Ala-Ala-Arg-Glu-Gly-Phe-Leu-Ala-Thr-Leu-Val-Val-Leu-His-Arg-Ala-Gly-Ala-Arg]

C93H155N31O26

2123.42

[1]Fåhraeus R, et al. Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule. Oncogene. 1998 Feb 5;16 (5) :587-96.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P1109/Ala92-p16-84-103-SDS-MedChemExpress.pdf

Reference compound1

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