ALAD Antilichaam

The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins) . ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.

210

P13716

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human ALAD (NP_000022.3) .

Unconjugated

Primary Antibodies

Cell Cycle

Affinity purification

HL-60

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 36kDa

IgG

ALAD

Mouse liver

Mouse kidney

Aminolevulinate dehydratase

Homo sapiens

ALAD, ALADH, MGC5057, PBGS

WB, IF

Liquid