Albomycine δ1

Albomycin δ1 is a selective bacterial ribosome-targeted antibiotic (MIC: 0.0625 μg/mL against S. pneumoniae) . Albomycin δ1 exerts bactericidal activity via covalent binding to 70S ribosomes and irreversible inhibition of peptidyl transferase. Albomycin δ1 is promising for research of S. pneumoniae and S. aureus infections[1][2].

12676-11-8

12352005

Antibiotic; Bacterial

Anti-infection

COVID-19-immunoregulation

Infection

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C36H55FeN10O18S

1003.79

[1]Lin Z, et al. Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens. Nat Commun. 2018 Sep 4;9 (1) :3445.|[2]Gadakh B, et al. Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase. Bioorg Med Chem. 2020 Sep 1;28 (17) :115645.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16459/

Natural Products

No Development Reported