Albomycine ε

Albomycin ε is a siderophore-antibiotic conjugate targeting bacterial ribosomes (MIC values:>512 μg/mL) . Albomycin ε is promising for research of Streptococcus pneumoniae and Staphylococcus aureus infections[1][2].

12676-10-7

12352005

Antibiotic; Bacterial

Anti-infection

Infection

O[C@H]1[C@H](O)[C@@H](N2C=CC(N(C)C2=O)=N)S[C@@]1([H])[C@H](O)[C@@H](C(O)=O)NC([C@H](CO)NC([C@@H](N3)CCCN(C(C)=O4)O[Fe]546(O7)ON(C(C)=O6)CCC[C@H](NC([C@H](CCCN7C(C)=O5)N)=O)C3=O)=O)=O

C36H56FeN11O17S

1002.80

[1]Lin Z, et al. Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens. Nat Commun. 2018 Sep 4;9 (1) :3445.|[2]Gadakh B, et al. Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase. Bioorg Med Chem. 2020 Sep 1;28 (17) :115645.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16461/

Natural Products

No Development Reported