ALD1613
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
ALD1613 is a potent neutralizing monoclonal antibody against adrenocorticotropic hormone (ACTH) . ALD1613 neutralizes ACTH-induced signaling and inhibits ACTH-induced cyclic AMP accumulation in a mouse adrenal cell line (Y1) via all five melanocortin receptors. ALD1613 significantly reduces plasma corticosterone levels in wild-type rats. ALD1613 can be used in the study of diseases associated with elevated ACTH levels[1].
12352203
Melanocortin Receptor
GPCR/G Protein; Neuronal Signaling
Metabolism-protein/nucleotide metabolism
Metabolic Disease
[ALD1613]
[1]Andrew L Feldhaus, et al. ALD1613, a Novel Long-Acting Monoclonal Antibody to Control ACTH-Driven Pharmacology. Endocrinology. 2017 Jan 1;158 (1) :1-8.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991221/
Inhibitory Antibodies
No Development Reported
Beschrijving
ALD1613 is a potent neutralizing monoclonal antibody against adrenocorticotropic hormone (ACTH) . ALD1613 neutralizes ACTH-induced signaling and inhibits ACTH-i
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