ALD1910

ALD1910 is a humanized monoclonal antibody against PACAP38 and PACAP27. ALD1910 blocks PACAP signaling through the pituitary adenylate cyclase-activating peptide type I receptor (PAC1-R), vasoactive intestinal peptide receptor 1 (VPAC1-R), and VPAC2-R. ALD1910 recognizes a nonlinear epitope within PACAP and blocks its binding to the cell surface. ALD1910 can be used for the study of PACAP-mediated migraine[1].

12352203

PACAP Receptor

GPCR/G Protein

Neuroscience-Neuromodulation

Neurological Disease

96.85

[1]Cristina Moldovan Loomis, et al. Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide. J Pharmacol Exp Ther. 2019 Apr;369 (1) :26-36.

Dry Ice

Store at -80°C for 2 years

http://file.medchemexpress.com/batch_PDF/HY-P991511/ALD1910-SDS-MedChemExpress.pdf

Inhibitory Antibodies

No Development Reported