ALDH2 Antilichaam

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

217

P05091

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 1-380 of human ALDH2 (NP_000681.2) .

Unconjugated

Primary Antibodies

Cancer, Signal Transduction

Affinity purification

Mouse lung

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 54kDa

IgG

ALDH2

Mouse liver

Aldehyde dehydrogenase 2 family (mitochondrial)

Homo sapiens

ALDH2, nucleus-encoded mitochondrial aldehyde dehydrogenase 2, mitochondrial aldehyde dehydrogenase 2, MGC1806, liver mitochondrial ALDH, ALDM, ALDHI, ALDH-E2, ALDH class 2, aldehyde dehydrogenase 2 family (mitochondrial), acetaldehyde dehydrogenase 2

WB, IHC, IF

Liquid