Aldh3A1 Antilichaam

Aldh3A1 Antibody: Aldh3A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD (P) (+) -dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldh3A1 is highly expressed in stomach and even more strongly in cornea, representing between 5 to 50% of the water soluble protein fraction in mammalian corneas. It is thought that Aldh3A1 acts to protect the cornea from UV-induced oxidative stress by not only detoxification of reactive aldehydes by also through the direct absorbtion of UV energy. However, corneas from Aldh3A1-null mice are indistinguishable from those from wild-type mice; mice lacking both Aldh3A1 and Aldh1A1 showed increased cataract formation following UVB exposure, suggesting that Aldh1A1 may be able to compensate for the loss of Aldh3A1.

218

P30838

NP_000682

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

Aldh3A1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1319 - Human Stomach Tissue Lysate

1 mg/mL

Aldh3A1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Aldh3A1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least two isoforms of Aldh3A1 are known to exist. This antibody is predicted to have no cross-reactivity to Aldh3A2.

ALDH3A1

Aldehyde dehydrogenase 3 family, memberA1

Homo sapiens

Vasiliou V and Pappa A. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. Pharmacology2000; 61:192-8.

Hsu LC, Chang WC, Shibuya A, et al. Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escheria coli. J. Biol. Chem.1992; 267:3030-7.

Pappa A, Sophos NA and Vasiliou V. Corneal and Stomach expression of aldehyde dehydrogenases: from fish to mammals. Chem. Biol. Interact.2001; 130:181-91.

Estey T, Cantore M, Weston PA, et al. Mechanisms involved in the protection of UV-induced protein inactivation by the corneal crystallin ALDH3A1. J. Biol. Chem.2007; 282:4382-92.

Aldh3A1 Antibody: ALDH3, ALDHIII, ALDH3, Aldehyde dehydrogenase, dimeric NADP-preferring

ELISA, WB

22907049

Liquid