Aldh5A1 Antilichaam

Aldh5A1 Antibody: Aldh5A1 is a member of the aldehyde dehydrogenase superfamily, a group of NAD (P) (+) -dependent enzymes that catalyze the oxidation of a wide spectrum of aliphatic and aromatic aldehydes. Aldehyde dehydrogenase enzymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. Aldh5A1 is a mitochondrial NAD (+) -dependent succinic semialdehyde dehydrogenase. A deficiency of this enzyme, known as 4-hydroxybutyricaciduria, results in a disorder of the neurotransmitter 4-aminobutyric acid (GABA) . Symptoms usually include static encephalopathy, associated with developmental delays, hypotonia, ataxia, speech defects, and seizures. At least two isoforms of Aldh5A1 are known to exist.

7915

P51649

NP_733936

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

Aldh5A1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1304 - Human Liver Tissue Lysate

1 mg/mL

Aldh5A1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Aldh5A1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ALDH5A1

Aldehyde dehydrogenase 5 family, member A1

Homo sapiens

Vasiliou V and Pappa A. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. Pharmacology2000; 61:192-8.

Hearl WG and Churchich JE. Interactions between4-aminobutyrate aminotransferase and succinic semialdehyde dehydrogenase, two mitochondrial enzymes. J. Biol. Chem.1984; 259:11459-63.

Gibson KM, Sweetman L, Nyhan WL, et al. Succinic semialdehyde dehydrogenase deficiency: an inborn error of gamma-aminobutyric acid metabolism. Clin. Chim. Acta1983; 133:33-42.

Aldh5A1 Antibody: SSDH, SSADH, Succinate-semialdehyde dehydrogenase, mitochondrial, Aldehyde dehydrogenase family 5 member A1

ELISA, WB

25777721

Liquid