Alfa-tubuline-antilichaam

Alpha-tubulin belongs to the tubulin superfamily, which is composed of six distinct families. Along with beta-tubulins, alpha-tubulins are the major components of microtubules. These microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Alpha- and beta-tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22-nm diameter (reviewed in 1) . Tyrosine ligase adds a C-terminal tyrosine to monomeric alpha-tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton-associated carboxypeptidase (2) . Another post-translational modification of detyrosinated alpha-tubulin is C-terminal polyglutamylation, which is characteristic of microtubules in neuronal cells and the mitotic spindle (3) . Like GAPDH and ?-Actin, this antibody makes an excellent loading control in immunoblots.

7278

Q13748

NP_005992

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Homeostasis

Alpha-tubulin antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Pig: (100%), Chicken: (100%)

Alpha-tubulin antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Alpha-tubulin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Alpha-tubulin antibody is human, mouse and rat reactive.

TUBA3C

Cat. No. 10-301 - Human Brain Tissue Slide

Tubulin, alpha 3c

Homo sapiens

McKean PG, Vaughan S, and Gull K. The extended tubulin family. J. Cell Sci. 2001; 114:2723-33.

Barra HA, Arce CA, and Argarana CE. Posttranslational tyrosination/detyrosination of tubulin. Mol. Neurobiol. 1988; 2:133-53.

Fukshima N, Furuta D, Hidaka Y, et al. Post-translational modifcations of tubulin in the nervous system. J. Neurochem. 2009; 109:683-693.

Alpha-tubulin Antibody: TUBA2, bA408E5.3, TUBA2, TUBA3D, Alpha-tubulin 2

ELISA, WB, IHC-P, IF

17921993

Liquid