Alfa-Tubulus-antilichaam [2B11]

Alpha-Tubulin belongs to the tubulin superfamily, which is composed of six distinct families. Along with beta-tubulins, alpha-Tubulins are the major components of microtubules. These microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintenance of cell shape. Alpha- and beta-tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22-nm diameter (reviewed in 1) . Tyrosine ligase adds a C-terminal tyrosine to monomeric alpha-Tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton-associated carboxypeptidase (2) . Another post-translational modification of detyrosinated alpha-Tubulin is C-terminal polyglutamylation, which is characteristic of microtubules in neuronal cells and the mitotic spindle (3) . Like GAPDH and ?-Actin, this antibody makes an excellent loading control in immunoblots.

7846

CAA25855

Human, Mouse, Rat, Rabbit, Zebrafish

Alpha-Tubulin antibody was raised against an 18 amino acid peptide near the carboxy terminus of human alpha-Tubulin

2B11

Unconjugated

Primary Antibodies

Homeostasis

Alpha-Tubulin antibody is affinity chromatography purified via peptide column.

Cat. No. 1303 - Human Brain Tissue Lysate

1 mg/mL

Alpha-Tubulin antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

Alpha-Tubulin antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

Alpha-Tubulin antibody is human, mouse, rat, rabbit, and zebrafish reactive.

TUBA1A

Tubulin, alpha 1a

Homo sapiens

McKean PG, Vaughan S, and Gull K. The extended tubulin family. J. Cell Sci. 2001; 114:2723-33.

Barra HA, Arce CA, and Argarana CE. Posttranslational tyrosination/detyrosination of tubulin. Mol. Neurobiol. 1988; 2:133-53.

Fukshima N, Furuta D, Hidaka Y, et al. Post-translational modifcations of tubulin in the nervous system. J. Neurochem. 2009; 109:683-693.

Tubulin alpha-1A, TUBA1A, TUBA3, LIS3

ELISA, WB

37492

Liquid