Alfasynucleïnecontrolepeptide (116-131), menselijk, gezuiverd Peptide

Alpha synuclein is an abundant 140 amino acid neuronal protein, expressed primarily at presynaptic terminals in the central nervous system. Alpha synuclein has been associated with several neurodegenerative diseases. A point mutation in the gene coding for the alpha-synuclein protein was the first discovery linking this protein to a rare familial form of Parkinson's disease (PD) . Subsequently, other mutations in the alpha-synuclein gene have been identified in familial PD. The aggregated proteinaceous inclusions called Lewy bodies found in PD and cortical Lewy body dementia (LBD) were discovered to be predominantly alpha-synuclein. Aberrant aggregation of alpha-synuclein has been detected in an increasing number of neurodegenerative diseases, collectively known as synucleopathies. Alpha-synuclein exists physiologically in both soluble and membrane-bound states, in unstructured and alpha-helical conformations, respectively. The physiological function of alpha-synuclein appears to require its translocation between these subcellular compartments and interconversion between the 2 conformations. Abnormal processing of alpha-synuclein is predicted to lead to pathological changes in its binding properties and function.

Alpha synuclein control peptide (116-131), purified human peptide, suitable to block.

Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP

P37840

Alpha-synuclein

Block

Purified

For research use only.

25°C (ambient)

This peptide is soluble in PBS and water. After reconstitution keep at -20°C. Avoid repetitive freeze/thaw cycles.

> 90% purity

Synthetic

Lyophilized