Alfuzosine (hydrochloride) -d6

Alfuzosin (hydrochloride) -d6 (SL 77499-10-d6) is deuterium labeled Alfuzosin (hydrochloride) . Alfuzosin (SL 77499-10) hydrochloride is an orally active, selective and competitive α1-adrenoceptor antagonist. Alfuzosin hydrochloride relaxes the muscles of the prostate and bladder neck, aiding in urination. Alfuzosin hydrochloride can be used in study of benign prostatic hyperplasia (BPH) [1][2].

1006717-24-3

SL 77499-10-d6

12352005

Adrenergic Receptor; Isotope-Labeled Compounds

GPCR/G Protein; Neuronal Signaling; Others

Metabolism-protein/nucleotide metabolism

Endocrinology

O=C(C1OCCC1)NCCCN(C)C2=NC3=C(C=C(C(OC([2H])([2H])[2H])=C3)OC([2H])([2H])[2H])C(N)=N2.Cl

C19H22D6ClN5O4

431.95

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Martin DJ, et al. Relationship between the effects of alfuzosin on rat urethral and blood pressures and its tissue concentrations. Life Sci. 1998;63 (3) :169-76. |[3]Wilde MI, et al. Alfuzosin. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in benign prostatic hyperplasia. Drugs. 1993 Mar;45 (3) :410-29.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-B0192S3A/

Isotope-Labeled Compounds

No Development Reported