Alimp1 Antilichaam

AIMP1 (Endothelial monocyte-activating polypeptide II, EMAP2) is a proinflammatory cytokine for monocytes and granulocytes (1) . It is specifically induced by apoptosis and is involved in the control of angiogenesis, inflammation, and wound healing (1,2) . AIMP1 was identified as one of three auxiliary factors of the mammalian aminoacyl tRNA synthetase (ARS) complex. It binds and facilitates the catalytic reaction of arginyl-tRNA synthetase (2,3) . Recent studies show that CD23 plays an essential role in the AIMP1-induced immune response and might be a target in the treatment of inflammatory diseases (4) .

9255

Q12904

NP_001135888

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Immunology

AIMP1 antibody is affinity chromatography purified via peptide column.

Cat. No. 1463 - Rat Brain Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Chicken: (73%)

AIMP1 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

AIMP1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

AIMP1 antibody is human, mouse and rat reactive. At least two isoforms of AIMP1 are known to exist; this antibody will recognize both isoforms. AIMP1 antibody is predicted to not cross-react with AIMP2.

AIMP1

Cat. No. 1303 - Human Brain Tissue Lysate

Cat. No. 1403 - Mouse Brain Tissue Lysate

Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

Homo sapiens

Park SG, Jung KH, Lee JS, et al. Precursor of pro-apoptotic cytokine modulates aminoacylation activity of tRNA synthetase. J. Biol. Chem. 1999; 274:16673–6.

Park SG, Shin H, Shin YK, et al. The novel cytokine p43 stimulates dermal fibroblast proliferation and wound repair. Am. J. Pathol. 2005; 166:387–98.

Quevillon S, Agou F, Robinson JC, et al. The p43 component of the mammalian multi-synthetase complex is likely to be the precursor of the endothelial monocyte-activating polypeptide II cytokine. J. Biol. Chem. 1997; 272:32573–9.

Kwon HS, Park MC, Kim DG, et al. Identification of CD23 as a functional receptor for the proinflammatory cytokine AIMP1/p43. J. Cell Sci. 2012; 125:4620-9.

AIMP1 Antibody: p43, HLD3, EMAP2, SCYE1, EMAPII, Aminoacyl tRNA synthase complex-interacting multifunctional protein 1, Multisynthase complex auxiliary component p43, EMAP-2

ELISA, WB, IHC-P

215490011

Liquid