Alissertib
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Alisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM) .1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.
Unconjugated
Off-white solid
-20°C
Beschrijving
Alissertib Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
Specificaties
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75009936
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Low Speed Refrigerated Centrifuge
LX104LSR
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LX117LSR
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1 Unit
Blood Bank Refrigerator
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Blood Bank Refrigerator
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