ALizarinecomplexon (dihydraat)

ALizarin complexone dihydrate is the dehydrate of Alizarin complexone. Alizarin complexone is a calcium-binding fluorescent dye. Alizarin complexone stains mineralized areas of bone by binding to calcium crystals. Alizarin complexone inhibits the reverse transcriptase activity of RAV-2, HIV-1, and RSV with IC50 values of 3.8 μg/mL, 45 μg/mL, and 100 μg/mL, respectively. Alizarin complexone exhibits antiviral activity against HIV-1 and RSV. Alizarin complexone delays RSV-induced tumor induction in chickens[1][2][3][4].

455303-00-1

12352005

H302-H315-H319-H335

Fluorescent Dye; HIV; Reverse Transcriptase; RSV

Anti-infection; Others

Metabolism-protein/nucleotide metabolism

Cancer; Infection; Metabolic Disease

O=C(CN(CC(C=C1C2=O)=C(C(O)=C1C(C3=C2C=CC=C3)=O)O)CC(O)=O)O.O.O

C19H19NO10

421.35

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

[1]Higuchi H, et al. Antiretroviral activities of anthraquinones and their inhibitory effects on reverse transcriptase. Antiviral Res. 1991;15 (3) :205-216. |[2]Oshima T, et al. Selective extraction of histidine derivatives by metal affinity with a copper (II) -chelating ligand complex in an aqueous two-phase system. J Chromatogr B Analyt Technol Biomed Life Sci. 2015;990:73-79. |[3]Yu T, et al. Live imaging of osteoclast inhibition by bisphosphonates in a medaka osteoporosis model. Dis Model Mech. 2016 Feb;9 (2) :155-63. |[4]Cui M, et al. New role of calcium-binding fluorescent dye alizarin complexone in detecting permeability from articular cartilage to subchondral bone. FASEB Bioadv. 2024 Oct 7;6 (11) :539-554.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W320523/

Biochemical Assay Reagents

No Development Reported