ALK Antilichaam

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2) /EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X) .

238

Q9UM73

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 19-300 of human ALK (NP_004295.2) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Growth Factors, Immunology, Neuroscience, Signal Transduction

Affinity purification

A-431

Batch dependent

PBS with 0.02% sodium azide, pH7.3.

None

Blue Ice

Store at 4˚ C. Avoid freeze / thaw cycles.

Observed: 185kDa

IgG

ALK

Anaplastic lymphoma receptor tyrosine kinase

Homo sapiens

CD246, NBLST3

WB, IHC

Liquid