ALK (fosfo-Tyr1096) Antilichaam

The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs) . The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain.

238

Q9UM73

NP_004295.2

Human, Mouse

ALK (phospho Tyr1096) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1096 (P-N-Y (p) -C-F) derived from Human ALK.

Unconjugated

Primary Antibodies

Phospho-Specific

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Phospho-Specific

Blue Ice

Store antibody at -20˚ C for up to one year.

176 kDa

IgG

The antibody detects endogenous levels of ALK only when phosphorylated at tyrosine 1096.

Alk

Anaplastic lymphoma receptor tyrosine kinase

Homo sapiens

Morris S.W., Oncogene 14:2175-2188 (1997) .

Morris S.W., Oncogene 15:2883-2883 (1997) .

Iwahara T., Oncogene 14:439-449 (1997) .

ALK tyrosine kinase receptor, anaplastic lymphoma kinase, anaplastic lymphoma kinase (Ki-1), CD246; EC 2.7.10.1, kinase ALK

IHC

110347475

Liquid